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![Spherical HDL](/images/ofmonth/2009-09/highlight-small.jpg)
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Cholesterol maintains a healthy body, but too much cholesterol can lead to atherosclerosis
and heart disease. Lipoproteins can bag superfluous cholesterol in the arteries and
transport it to the liver for removal. One such lipoprotein is high-density lipoprotein
(HDL) which self-assembles into discoidal particles (see the Mar 2007
highlight) and then bags cholesterol. How this works is the subject of a recent
report. Molecular dynamics simulations using NAMD revealed that discoidal HDL
particles, teaming up with the enzyme LCAT, first turn cholesterol chemically into
cholesterol ester and then sucks it into the interior of the particle; in the course of
this process, the HDL particle swells into a sphere. More information on our lipoprotein website.