Highlights of our Work

Highlight: Seeing is Believing

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This year, the Royal Swedish Academy of Sciences awarded the Nobel Prize in Chemistry to Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution". We are pleased to celebrate this great triumph for structural biology along with the well-deserved recognition of the Center's long-time collaborator and friend, Joachim Frank. Our center has a long tradition in developing computational methods that enable scientists to build atomistic models of biomolecules. Molecular Dynamics Flexible Fitting (MDFF), a method developed in close collaboration with Joachim Frank and his group, reconciles high resolution data from X-ray crystallography and functional information from cryo-electron microscopy (cryo-EM). MDFF utilizes molecular dynamics to "naturally" fit each atom into a cryo-EM map. In less than a decade since its development, MDFF has proved instrumental in studying biomolecular systems. A selected list of publications employing MDFF both by our group and others can be found here.
Editorials

The Future of Biomolecular Modeling

A 2015 TCBG Symposium brought together scientists from across the Midwest to brainstorm about what's on the horizon for computational modeling. See a summary of what these experts foresee. Read more

Magnetic Sense of Birds

How do birds sense magnetic fields? Theoretical and computational biology may provide tools to unearth the answer. Researchers are combining behavioral studies with physics and chemistry to unlock the enigma of this sixth sense. By Lisa Pollack Read more
Remembering
Klaus Schulten
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November 7-9, 2017

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Titan Helps Researchers Suck Mystery Out of Cell's 'Vacuum Cleaners'Researchers Discover Physical Properties of HIV Capsid in Interaction with its EnvironmentAll-Atom Simulation of ATP Synthase by Center ResearchersTajkhorshid named the J. Woodland Hastings Endowed Chair in Biochemistry

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Barry Isralewitz, Postdoctoral Associate

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