The recent pandemic has underscored the critical importance of understanding viral structure and function to prevent their spread. By employing a multiresolution simulation approach that utilizes ARBD and NAMD 3.0, researchers at the Resource revealed how a DNA virus organizes its genome through repeated tight folding of the DNA rather than the traditional view often depicted in textbooks. Atomistic simulations further confirmed consistency with available experimental data, including pressure and average structure. These groundbreaking findings were recently published in Nature.