Paper Citing NAMD - Abstract
Politis, Argyris; Stengel, Florian; Hall, Zoe; Hernandez, Helena; Leitner, Alexander; Walzthoeni, Thomas; Robinson, Carol V.; Aebersold, Ruedi
A mass spectrometry-based hybrid method for structural modeling of protein complexes
NATURE METHODS, 11:403-+, APR 2014
We describe a method that integrates data derived from different mass spectrometry (MS)-based techniques with a modeling strategy for structural characterization of protein assemblies. We encoded structural data derived from native MS, bottom-up proteomics, ion mobility-MS and chemical cross-linking MS into modeling restraints to compute the most likely structure of a protein assembly. We used the method to generate near-native models for three known structures and characterized an assembly intermediate of the proteasomal base.
