Wilson, James; Di Ventra, M.
Single-base DNA discrimination via transverse ionic transport
NANOTECHNOLOGY, 24 Art. No. 415101, OCT 18 2013

We suggest the discrimination of single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular dynamics simulations indeed show that the ionic currents of the four bases are statistically distinct, thus offering another possible approach to sequencing DNA.

DOI:10.1088/0957-4484/24/41/415101

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