Structural Biology Software Database
Structural Biology Software Database

Application Index Record

Category: Molecular Docking
Last Update: 04-26-2006

LEAPFROG is a powerful, second generation de novo ligand design tool that proposes a series of new, potentially active ligand molecules, even when the receptor structure is not known. LeapFrog generates new compounds by repeatedly making small structural changes, rapidly evaluating the binding energy of the new compound, and keeping or discarding the changes based on the results.


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