Structural Biology Software Database
Application Index Record
| Category: Miscellaneous |
| DISCO (DIStance COmparison) |
| Last Update: 12-31-2000 |
| Description: DISCO rapidly generates multiple pharmacophore hypotheses for a given set of active compounds. Using fast computing techniques and a method of clique detection developed by Dr. Yvonne Martin and co-workers at Abbott Laboratories, DISCO identifies common pharmacophoric features in each structure, produces optimally aligned structures, and extracts the key features of the pharmacophore. These pharmacophore hypotheses can then be compared, refined, and used to guide lead generation and lead optimization. |
| Homepage: http://www.tripos.com/software/disco.html |
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