Home Department: Biophysics
Beckman Institute, Room 3117
University of Illinois at Urbana-Champaign
405 N. Mathews
Urbana, IL 61801
Office Phone: 217-244-1851
Email Address: email@example.com
- Ph.D. in Biophysics, UIUC, 2016 (expected)
- B.S. in Physics, Peking University, 2010
Research InterestsI'm interested in understanding structure-function relationships of biomolecules. Specifically I use physical models and simulation tools to link atomistic structures to molecular functions. One important case involves molecular machines, which play vital roles in various processes of living cells. It is a mystery how the chemical energy from ATP is utilized by many molecular machines to fulfill their functions. By combining molecular dynamics simulations with statistical physics, the molecular mechanism and energy landscape of these machines can now be characterized. See our representative publication, as well as our research website here.
Related Research Categories: (publications in parentheses)
(1) Mechanism of substrate translocation by a ring-shaped ATPase motor at millisecond resolution. W. Ma and K. Schulten, Journal of the American Chemical Society, 137 (8), 3031-3040, 2015.
(2) Recognition of methylated DNA through methyl-CpG binding domain proteins. X. Zou, W. Ma , I. A. Solov'yov, C. Chipot, and K. Schulten, Nucleic Acids Research, 40 (6), 2747-2758, 2012.
(3) Theoretical and computational investigation of flagellin translocation and bacterial flagellum growth. D. E. Tanner, W. Ma , Z. Chen, K. Schulten. Biophysical Journal, 100 (11), 2548-2556, 2011.
- Resolving Molecular Motor Action, June, 2015. See CPLC news, Univeristy of Illinois; also see TCBG news, Beckman Institute.
Awards and Honors
- Graduate College travel grant for Gordon Research Conference - Proteins, 2015
- Travel award, Biophysical Society 2015 annual meeting
- Wusi fellowship, Peking University, 2007~2009
- Freshman scholarship, Peking University, 2006
Talks and Lectures
- Talk: "Molecular Dynamics Study of Directional Translocation and Subunit Coordination in a Hexameric Helicase Motor." NSF's Physics of Living Systems (PoLS) annual meeting, Yale University, July 2012.
- Talk: "Computational Study of RNA Translocation in a Hexameric Helicase." 57th Biophysical Society annual meeting, Philadelphia, February 2013.
- Talk: "Study of Conformational Transitions of Molecular Machines Using the String Method." Annual meeting of the Membrane Protein Structural Dynamics Consortium, Chicago, May 2013.
- Invited Talk: "Physical Mechanism of Rho Hexameric Helicase." Center for the Physics of Living Cells (CPLC) symposium, University of Illinois, October 2013.
- "Force Generation Mechanism of Molecular Motors." Poster section for NSF site visit to CPLC, University of Illinois, April 2013.
- "RNA Translocation Coupled to Large-Scale Conformational Transitions of a Hexameric Helicase." 59th Biophysical Society annual meeting, Baltimore, February 2015.
- "Mechanism of Substrate Translocation by a Ring-Shaped ATPase Motor at Millisecond Resolution." Gordon Research Conference: Proteins, Holderness, June 2015.