Home Department: Center for Biophysics and Quantitative Biology

Email Address: aarango2@illinois.edu

Doctoral Advisor: Dr. Emad Tajkhorshid


Research Interests

  • Amyloid Beta fibrils and pore formation
  • Endogenous and exogenous anti- and pro-inflammatory compounds
  • Endocytosis and fusion mechanisms
  • Lipid-protein interactions
  • Phthalate and fatty acid interactions with nuclear receptors
  • Cytochrome P450 small molecule interactions
  • Topological data analysis for molecular simulations
Ensemble docking of anthracyclines onto CYP2J2


Selected Publications

D. D. Meling, K. M. De La Torre, A. S. Arango, A. R. K. Deviney, A. M. Neff, M. J. Laws, G. R. Warner, E. Tajkhorshid, and J. A. Flaws (2022)
Phthalate Metabolites Act Through Peroxisome Proliferator-Activated Receptors (PPAR) in the Mouse Ovary.
Reproductive Toxicology, in press.

J. S. Kim*, A. S. Arango*, S. Shah, W. R. Arnold, E. Tajkhorshid, A. Das (2022)
Anthracycline Derivatives Inhibit Cardiac CYP2J2.
J. Inorg. Biochem., 229, 111722.

Alzheimer Imaging
L. Sun, H.-J. Cho, S. Sen, A. S. Arango, T. T. Huynh, Y. Huang, N. Bandara, B. E. Rogers, E. Tajkhorshid, and L. M. Mirica (2021)
Amphiphilic Distyrylbenzene Derivatives as Potential Therapeutic and Imaging Agents for Soluble and Insoluble Amyloid β Aggregates in Alzheimer's Disease.
JACS, 143: 10462-10476.

Micelle solubilized amyloid beta oligomer
S. Ciudad, E. Puig, T. Botzanowski, M. Meigooni, A. S. Arango, J. Do, M. Mayzel, M. Bayoumi, S. Chaignepain, G. Maglia, S. Cianferani, V. Orekhov, E. Tajkhorshid, B. Bardiaux, and N. Carulla (2020)
Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage.
Nature Communications, 11: 3014.

CoxFluor bound to COX-2
A. K. Yadav*, C. J. Reinhardt*, A. S. Arango, H. C. Huff, L. Dong, M. G. Malkowski, A. Das, E. Tajkhorshid, and J. Chan (2020)
An Activity-based Sensing Approach for the Detection of Cyclooxygenase-2 in Live Cells.
Angewandte Chemie, 59: 3307-3314.

R. P. Sparks*, A. S. Arango*, J. L. Jenkins, W. C. Guida, E. Tajkhorshid, C. E. Sparks, J. D. Sparks, and R. A. Fratti (2020)
An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL and PCSK9 Altering LDLR Expression Levels in Hepatocytes.
Biochemistry, 59: 4321-35.

R. P. Sparks*, A. S. Arango*, M. L. Starr*, Z. L. Aboff, K. A. Harden, J. L. Jenkins, W. C. Guida, E. Tajkhorshid, and R. A. Fratti (2019)
A Small Molecule Competitive Inhibitor of Phosphatidic Acid Binding by Sec18 Blocks the SNARE Priming Stage of Vacuole Fusion.
J. Biol. Chem., 294: 17168-17185. JBC EDITORS' PICK (top 2% in significance and importance)


M. L. Starr*, R. P. Sparks*, A. S. Arango*, L. R. Hurst, Z. Zhao, M. Lihan, J. L. Jenkins, E. Tajkhorshid, and R. A. Fratti (2019)
Phosphatidic acid induces conformational changes in Sec18 protomers that prevent SNARE priming.
J. Biol. Chem., 294: 3100-3116.

Virodhamien CYP2J2
L. N. Carnevale, A. S. Arango, W. R. Arnold, E. Tajkhorshid*, and A. Das* (2018) Endocannabinoid Virodhamine is an Endogenous Inhibitor of Human Cardiovascular CYP2J2 Epoxygenase. Biochemistry, 57: 6489-6499.

* Denotes equal contribution

Doctoral Defense Presentation

Theoretical and Computational Investigations of Membrane Associated Pathology


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