TCBG Seminar

3D electron microscopy comes of age: Biological applications and technological frontiers

Dr. Sriram Subramaniam
Laboratory of Cell Biology
Center for Cancer Research National Cancer Institute
Bethesda, MD

Monday, January 26, 2015
3:00 pm (CT)
3269 Beckman Institute


Recent breakthroughs in the field of cryo-electron microcopy provide new prospects for determination of the structures of a variety of macromolecular assemblies and small dynamic protein complexes that are not amenable to analysis by X-ray crystallography or NMR spectroscopy. In addition, advances in technologies for imaging whole cells and tissues in 3D at high resolution have opened up new vistas for 3D structural imaging. I will review emerging opportunities in molecular and cellular imaging that are enabled with these developments, and discuss applications to cancer research in the coming decade.

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