Paper Citing VMD - Abstract
Kleczkowski, Leszek A., Geisler, Matt, Fitzek, Elisabeth, Wilczynska, Malgorzata
A common structural blueprint for plant UDP-sugar-producing pyrophosphorylases
BIOCHEMICAL JOURNAL, 439:375-379, NOV 1 2011 2011
Plant pyrophosphorylases that are capable of producing UDP-sugars, key precursors for glycosylation reactions, include UDP-glucose pyrophosphorylases (A- and B-type), UDP-sugar pyrophosphorylase and UDP-N-acetylglucosamine pyrophosphorylase. Although not sharing significant homology at the amino acid sequence level, the proteins share a common structural blueprint. Their structures are characterized by the presence of the Rossmann fold in the central (catalytic) domain linked to enzyme-specific N-terminal and C-terminal domains, which may play regulatory functions. Molecular mobility between these domains plays an important role in substrate binding and catalysis. Evolutionary relationships and the role of (de)oligomerization as a regulatory mechanism are discussed.
