Casanovas, J.; Revilla-Lopez, G.; Bertran, O.; del Valle, L. J.; Turon, P.; Puiggali, J.; Aleman, C.
Restricted Puckering of Mineralized RNA-Like Riboses
JOURNAL OF PHYSICAL CHEMISTRY B, 118:5075-5081, MAY 15 2014

The pseudorotational motions of highly hydroxylated pentafuranose sugars in the free state and tethered to hydroxyapatite have been compared. The conformation pentafuranose ring remains restricted at the North region of the pseudorotational wheel, which is the one typically observed for nucleosides and nucleotides in the double helix A-RNA, when the phosphate-bearing sugar is anchored to the mineral surface. Results indicate that the severe restrictions imposed by the mineral are responsible of the double helix preservation when DNA and RNA are encapsulated in crystalline nanorods.

DOI:10.1021/jp501714q

Find full text with Google Scholar.