Paper Citing NAMD - Abstract
Kostyuchenko, Victor A.; Zhang, Qian; Tan, Joanne L.; Ng, Thiam-Seng; Lok, Shee-Mei
Immature and Mature Dengue Serotype 1 Virus Structures Provide Insight into the Maturation Process
JOURNAL OF VIROLOGY, 87:7700-7707, JUL 2013
Dengue virus is a major human pathogen that has four serotypes (DENV1 to -4). Here we report the cryoelectron microscopy (cryo-EM) structures of immature and mature DENV1 at 6- and 4.5-angstrom resolution, respectively. The subnanometer-resolution maps allow accurate placement of all of the surface proteins. Although the immature and mature viruses showed vastly different surface protein organizations, the envelope protein transmembrane (E-TM) regions remain in similar positions. The pivotal role of the E-TM regions leads to the identification of the start and end positions of all surface proteins during maturation.
