Paper Citing NAMD - Abstract
Alies, Bruno; LaPenna, Giovanni; Sayen, Stephanie; Guillon, Emmanuel; Hureau, Christelle; Faller, Peter
Insights into the Mechanisms of Amyloid Formation of Zn-II-Ab11-28: pH-Dependent Zinc Coordination and Overall Charge as Key Parameters for Kinetics and the Structure of Zn-II-Ab11-28 Aggregates
INORGANIC CHEMISTRY, 51:7897-7902, JUL 16 2012
Self-assembly of amyloidogenic peptides and their metal complexes are of multiple interest including their association with several neurological diseases. Therefore, a better understanding of the role of metal ions in the aggregation process is of broad interest. We report pH-dependent structural and aggregation studies on Zn-II binding to the amyloidogenic peptide Ab11-28. The results suuest that coordination of the N-terminal amine to Zn-II is responsible for the inhibition of amyloid formation and the overall charge for amorphous aggregates.
