Pazos, Elena; Perez, Miguel; Gutierrez-de-Teran, Hugo; Orzaez, Mar; Guevara, Tatiana; Mascarenas, Jose L.; Eugenio Vazquez, M.
Rational design of a cyclin A fluorescent peptide sensor
ORGANIC & BIOMOLECULAR CHEMISTRY, 9:7629-7632, 2011

We report the design and development of a fluorescent sensor specifically designed to target cyclin A, a protein that plays a key role in the regulation of the cell cycle. Computational studies provide a molecular picture that explains the observed emission increase, suggesting that the 4-DMAP fluorophore in the peptide is protected from the bulk solvent when inserted into the hydrophobic binding groove of cyclin A.

DOI:10.1039/c1ob06009k

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