Paper Citing NAMD - Abstract
Espinoza-Fonseca, L.M.; Trujillo-Ferrara, J.G.
The existence of a second allosteric site on the M-1 muscarinic acetylcholine receptor and its implications for drug design
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16:1217-1220, MAR 1 2006
Fully flexible docking of KT5720, an allosteric modulator of the muscarinic receptors, was performed on a dynamic model of the M-1 muscarinic acetylcholine receptor. The results confirmed the existence of a second allosteric site, located on the intracellular face of the receptor. These results would be beneficial for the design of modulators of this receptor to be used as an effective alternative against the Alzheimer's disease. (C) 2005 Published by Elsevier Ltd.
