Mehmet Sarikaya, Candan Tamerler, Alex K. -Y. Jen, Klaus Schulten, and
François Baneyx.
Molecular biomimetics: nanotechnology through biology.
Nature Materials, 2:577-585, 2003.
SARI2003
Proteins, through their unique and specific interactions with
other macromolecules and inorganics, control
structures and functions of all biological hard and soft
tissues in organisms. Molecular biomimetics is an
emerging field in which hybrid technologies are developed by
using the tools of molecular biology and
nanotechnology. Taking lessons from biology, polypeptides can
now be genetically engineered to specifically
bind to selected inorganic compounds for applications in
nano- and biotechnology. This review discusses
combinatorial biological protocols, that is, bacterial cell
surface and phage-display technologies, in the
selection of short sequences that have affinity to (noble)
metals, semiconducting oxides and other
technological compounds. These genetically engineered
proteins for inorganics (GEPIs) can be used in the
assembly of functional nanostructures. Based on the three
fundamental principles of molecular recognition,
self-assembly and DNA manipulation, we highlight successful
uses of GEPI in nanotechnology.
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