Juan R. Perilla, Boon Chong Goh, John Stone, and Klaus Schulten.
Chemical visualization of human pathogens: the Retroviral
Capsids.
Proceedings of the 2015 ACM/IEEE Conference on
Supercomputing, 2015.
(4 pages).
PERI2015A
Retroviruses are pathogens characterized by their ability to
incorporate viral DNA into a host cell's genome. Retroviruses like
Rous Sarcoma Virus (RSV) infect cells during mitosis, when the
chromatin is exposed to the cytoplasm. Conversely, the genus of
lentiviruses, like the human immunodeficiency virus (HIV), have
evolved to infect non-dividing cells. Despite
infecting cells at different stages of their life cycles, RSV and HIV
share a similar late stage replication cycle that is highly dependent
on the group actin polyprotein precursor (Gag), which contains the
matrix (MA), capsid (CA) and nucleocapsid (NC) proteins. Both HIV's CA
and Gag are considered unexploited targets for pharmaceutical
intervention. We describe the techniques that were used to build,
simulate, analyze and visualize the structures of both Gag and CA,
and we discuss scientific visualization needs that spurred
development of an interactive GPU-accelerated ray tracing engine and
the use of remote visualization technologies.
Download Full Text
The manuscripts available on our site are provided for your personal
use only and may not be retransmitted or redistributed without written
permissions from the paper's publisher and author. You may not upload any
of this site's material to any public server, on-line service, network, or
bulletin board without prior written permission from the publisher and
author. You may not make copies for any commercial purpose. Reproduction
or storage of materials retrieved from this web site is subject to the
U.S. Copyright Act of 1976, Title 17 U.S.C.
