Structural Biology Software Database
Application Index Record
| Category: Protein Structure Analysis and Verification |
| ProFlex |
| Last Update: 05-07-2009 |
| Description: MSU ProFlex (formerly called FIRST) is a patented computational tool for identifying rigid and flexible regions in protein structures and protein-ligand complexes. Analysis of a single, static three-dimensional protein structure can capture the essential conformational flexibility of the protein. Hydrogen bonds, salt bridges and hydrophobic contacts are identified by geometric and energetic criteria once polar hydrogens have been placed using an external program (such as What If). Using a constraint counting algorithm, all-atom calculations on proteins of over 1000 residues can be completed within seconds. This software is available as source code and has been applied to many proteins and their complexes. |
| Homepage: http://www.bch.msu.edu/~kuhn/software/proflex/ |
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