Tianle Chen

tianle

Home Department: Center for Biophysics and Computational Biology

Office Address: Beckman Institute, Room 3027, 405 N Mathews Ave, Urbana, IL 61801

Email Address: tianle2@illinois.edu

Education

  • B.S. in Biophysics, Nanjing University, Nanjing, China, 2018
  • Ph.D. in Biophysics, UIUC, urbana, IL, 2025 (expected)

Research Interets

SARS-CoV-2 spike protein

  • Twisting and bending motion of spike head and stalk regions.
  • Post-translational modifications modulate the protein dynamics and membrane curvature.
  • Glycan-lipid and glycan-glycan interactions amplify protein's dynamical range.

Human Anion Exchanger 1

  • Anions bind to R730 in both outward-facing and inward-facing states.
  • OF to IF state transition induced with enhanced sampling method.
  • PIP2 modulates the AE1 activity by interacting with the hairpin region and increasing transition free energy.

Human acetylcholine receptors

  • Inserting residues at pre-M1 linker causes decoupling of extracellular and transmembrane domains.
  • Modeling and simulating the mutants reveal separation and decreased covariance of two domains.