Matt Sinclair
Home Department: Department of Biochemistry
Email Address: mts7@illinois.edu
Doctoral Advisor: Dr. Emad Tajkhorshid
Education
- B.A. in Biochemistry , University of Iowa, 2016
Undergraduate Advisor: Dr. Adrian Elcock
Research Interests
- Biophysical simulation
- Small molecule discovery
- Cheminformatics and machine learning
Awards
- Biochemistry Travel Award - 2020, 2023
Selected Publications
K. A. Munoz, R. J. Ulrich, A. K. Vasan, M. Sinclair, P. Wen, J. R. Holmes, H. Y. Lee, C. Hung, C. J. Fields, E. Tajkhorshid, G. W. Lau, and P. Hergenrother (2024)
A Gram-negative-selective antibiotic that spares the gut microbiome.
Nature.
A Gram-negative-selective antibiotic that spares the gut microbiome.
Nature.
M. Sinclair, R. A. Stein, J. H. Sheehan, E. M. Hawes, R. M. O'Brien, E. Tajkhorshid, D. P. Claxton (2024)
Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model.
PNAS Nexus.
Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model.
PNAS Nexus.
Q. Tang, M. Sinclair, H. S. Hasdemir, R. A. Stein, E. Karakas, E. Tajkhorshid, H. S. McHaourab (2023)
Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nature Communications.
Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Nature Communications.
J. Zhang, ..., M. Sinclair, E. Tajkhorshid, et al. (2024)
WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.
Nucleic Acids Research.
WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.
Nucleic Acids Research.
Artwork
Made with VMD
Monochromatic biology
Metabolic thalassaphobia
