Seminar
Parallel Pathways in Protein Folding: X-Ray Measurements and Computer Simulations
Professor Sebastian DoniachApplied Physics and Physics
Stanford University
Wednesday, November 17, 1999
3:00 pm
2269 Beckman Institute
Abstract
Folding of proteins from the
denatured to native state is a very complex dynamical process. In
recent years it has become clear that one cannot define a single
pathway in the ordinary sense of chemical reactions, but that a
proper description of folding must involve a multitude of pathways
defining various transition state ensembles which help to nucleate
the folding process. Time-resolved small-angle x-ray scattering data
will be presented which demonstrate the diversity of folding
processes for different small proteins. A new approach to computer
simulation of the folding process at atomic resolution will be
presented in which the statistics of different folding pathways is
sampled by reaction path annealing.
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Tea and coffee will be served in R3151 Beckman Institute at 2:15pm.
