VARG2012
Developing an understanding of the mechanism of voltage-gated ion channels in molecular
terms requires knowledge of the structure of the active and resting conformations.
Although the active state conformation is known from X-ray structures, an atomic-
resolution structure of a voltage-dependent ion channel in the resting state is not currently
available. This has motivated various efforts at using computational modeling methods and
molecular dynamics (MD) simulations to provide the missing information. A comparison of
recent computational results reveals an emerging consensus on voltage-dependent gating
from computational modeling and molecular dynamics simulations. This progress is
highlighted in the broad context of pre-existing work about voltage-gated channels.
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