TCB Publications - Abstract

TCB Publications - Abstract

B. Luan and A. Aksimentiev. Strain softening in stretched DNA. Physical Review Letters, 101:118101, 2008.

LUAN2008A-AA The microscopic mechanics of DNA stretching was characterized using extensive molecular dynamics simulations. By employing an anisotropic pressure-control method, realistic force-extension dependences of effectively infinite DNA molecules were obtained. A coexistence of B and S DNA domains was observed during the overstretching transition. The simulations revealed that strain softening may occur in the process of stretching torsionally constrained DNA. The latter observation was qualitatively reconciled with available experimental data using a random-field Ising model.

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