TCB Publications - Abstract

Daniel T. Infield, Ali Rasouli, Grace G. Galles, Christophe Chipot, Emad Tajkhorshid, and Christopher A. Ahern. Cation-π interactions and their functional roles in membrane proteins. Journal of Molecular Biology, 433:167035, 2021. Published. (PMC: PMC8338773)

INFI2021-ET Membrane proteins rely on diverse molecular forces to execute essential physiological tasks. Cation- interactions arise as a result of strong attractive forces between positively charged entities and the -electron cloud of aromatic groups. The physicochemical characteristics of cation- interactions are particularly well-suited to the dual hydrophobic/hydrophilic environment of membrane proteins, and they have been shown to play important roles in membrane protein function. As high-resolution structural data of membrane proteins bring molecular features into increasingly sharper view, cation- interactions are gaining traction as essential contributors to membrane protein chemistry, function, and pharmacology. Herein, after briefly reviewing the physicochemical properties of cation- interactions, we present several examples of prominent cation- interactions in ion channels and other membrane proteins, and we highlight their specific functional roles.


Request Full Text

Request Paper

Full Name
Email Address
Institution
Type the number eight in the box