Andrew Hitchcock, C. Neil Hunter, and Melih Sener.
Determination of cell doubling times from the return-on-investment
time of photosynthetic vesicles based on atomic detail structural models.
Journal of Physical Chemistry B, 121:3787-3797, 2017.
HITC2017-MS
Cell doubling times of the purple bacterium Rhodobacter sphaeroides
during photosynthetic growth are determined experimentally and
computationally as a function of illumination. For this purpose, energy
conversion processes in an intracytoplasmic membrane vesicle, the
chromatophore, are described based on an atomic detail structural model.
The cell doubling time and its illumination dependence are computed in
terms of the return-on-investment (ROI) time of the chromatophore,
determined computationally from the ATP production rate, and the mass
ratio of chromatophores in the cell, determined experimentally from whole
cell absorbance spectra. The ROI time is defined as the time it takes to
produce enough ATP to pay for the construction of another chromatophore.
The ROI time of the low light-growth chromatophore is 4.5-2.6 h for a
typical illumination range of 10-100 mol photons
m-2s-1, respectively, with
corresponding cell doubling times of 8.2-3.9 h. When energy expenditure is
considered as a currency, the benefit-to-cost ratio computed for the
chromatophore as an energy harvesting device is 2-8 times greater than
for photovoltaic and fossil fuel-based energy solutions and the
corresponding ROI times are approximately 3-4 orders of magnitude
shorter for the chromatophore than for synthetic systems.
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