Mu Gao, Marcos Sotomayor, Elizabeth Villa, Eric Lee, and Klaus Schulten.
Molecular mechanisms of cellular mechanics.
Physical Chemistry - Chemical Physics, 8:3692-3706, 2006.
GAO2006A
Mechanical forces play an essential role in cellular processes as input, output, and signals. Various protein complexes in the cell are designed to handle, transform and use such forces.
For instance, proteins of muscle and the extracellular matrix can withstand considerable stretching forces, hearing-related proteins can transform weak mechanical stimuli into electrical signals, and regulatory proteins are suited to force DNA into loops to control gene
expression. Here we review the structure-function relationship of four protein complexes with well defined and representative mechanical functions. The first example is titin, a protein that confers the passive elasticity on muscle. The second system is the elastic extracellular matrix protein, fibronectin, and its cellular receptors, integrins. The third protein system is the transduction apparatus in the inner ear likely containing cadherin and ankyrin repeats. The last system is the lac repressor protein, which regulates gene expression by looping DNA. This review focuses on atomic level descriptions of the physical mechanisms underlying the various mechanical functions of the stated proteins.
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