All movies and images were made using VMD. Download movie files via the movie file type (.mpg, .mov) after the movie title (right-click in Windows; control-click on Macs). To view original movie files, you may need to try the Quicktime or VLC movie players. You may wish to also visit TCBG's YouTube movie gallery to view science movies. All movies are copyrighted by TCBG.

First Spontaneous Ligand Binding Simulated (.mov, 2.9M)
The movie shows a 0.1 microsecond simulation of adenosine diphosphate (ADP - the red, blue, green spheres at top) spontaneously binding to the amino acids (blue and green sticks) of a protein (white curly structures). The transport of ADP by the protein is a key step in producing adenosine triphosphate, which provides energy for most cellular functions.
Finding a Pathway for Flu Drugs (.mov, 7.4M)
This movie, derived from molecular dynamics simulations, depicts the antiviral drug Tamiflu (shown in the center of the screen in blue, white, and pink) traveling along a binding pathway on neuraminidase (larger red, white, and blue mass), a protein responsible for replication of the flu virus. Tamiflu must avoid mutations along the pathway, or find a new binding pathway, on the protein to be effective. Understanding how mutations block drug paths can potentially lead to better drugs for influenza, avian, and swine flus.
Spelunking Through Myoglobin (.mov, 3.6M)
Myoglobin is a protein that stores oxygen (O2) in muscle cells to ensure a steady supply of O2 when it is needed. The movie shows the network of cavities and pathways in myoglobin that are accessible to O2. Within the accessible areas (shown in green), very favorable O2 binding pockets are shown in red, and slightly less favorable transient passages are in blue.