From: Raman Preet Singh (
Date: Thu Jun 16 2022 - 08:23:34 CDT

Strip water, that will reduce the size considerably (tens to a few hundred MB, depending on how much water is there).

Get Outlook for Android<;!!DZ3fjg!-2TUQ_VrjuFFyfWDPekpyzonaDqB0YXQKjV4JfHLqB5WemHZiS71bouFeIU9OpP7wmc--REtfMBQWt2jIZ8D1wJP-JXT$ >
From: <> on behalf of Efthymiou, Christos <>
Sent: Thursday, June 16, 2022 3:44:03 PM
To: <>
Subject: vmd-l: How to reduce the size of a .dcd file?


I have run several molecular dynamics simulations on a protein-protein complex that I would like to analyze with different python programs I have found online. However, the file size of my production run is around 5 GB and seems to overwhelm the programs and the memory I have on my computer. Is there a way to reduce the size of a .dcd file? For example, create a new .dcd file that only has every 50th frame of the original? I have a Windows 10 computer with the 32bit and 64bit versions of VMD available.

Thanks in advance.