Badu, Shyam; Melnik, Roderick; Prabhakar, Sanjay
RNA Nanostructures in Physiological Solutions: Multiscale Modeling and Applications
PHYSICS OF LIQUID MATTER: MODERN PROBLEMS, 171:337-355, 2015

In this review chapter we focus on the nucleic acid nanotechnology research and its application in the biomedical field. We also describe some of our most recent results on the modeling of ribonucleic acid (RNA) nanotubes and their characteristics in physiological solutions. This includes the properties that can be characterised by root mean square deviation (RMSD), radius of gyration and radial distribution function (RDF) for the RNA nanoclusters, paying special attention to RNA nanotubes. We describe the distribution of Na-23(+) and Cl-35(-) ions around the tube as a function of time within a distance of 5 angstrom from the surface of the tube. The results obtained from our computational studies are compared with available experimental results in the literature. The current developments in the coarse grain modeling of the RNA nanoclusters and other biomolecules are also highlighted.

DOI:10.1007/978-3-319-20875-6_13

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