Paper Citing NAMD - Abstract
Guo, Wei Wei; Wan, Dun; Liao, Li Fu; Lin, Ying Wu
Unusual peroxidase activity of a myoglobin mutant with two distal histidines
CHINESE CHEMICAL LETTERS, 23:741-744, JUN 2012
By retaining the native distal His64 in sperm whale myoglobin (Mb), a second distal histidine was engineered in Mb by mutating Leu29 to His29. The resultant mutant of L29H Mb exhibits an unusual enhanced peroxidase activity with a positive cooperativity in comparison to that of wild type Mb. The new enzyme with two cooperative distal histidines has not been found in native peroxidase, which emphasizes a creation of the rational protein design. (C) 2012 Ying Wu Lin. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
