Paper Citing NAMD - Abstract
Kunji, Edmund R. S.; Robinson, Alan J.
Coupling of proton and substrate translocation in the transport cycle of mitochondrial carriers
CURRENT OPINION IN STRUCTURAL BIOLOGY, 20:440-447, AUG 2010
Members of the mitochondrial carrier family are involved in transporting keto acids, amino acids, nucleotides, inorganic ions and co-factors across the mitochondrial inner membrane. The transporters are thought to share the same structural fold, which consists of six trans-membrane alpha-helices and three matrix helices, arranged with threefold pseudo-symmetry. During the transport cycle two salt bridge networks on either side of the central cavity might regulate access to a single substrate binding site in an alternating fashion. In the case of proton-substrate symporters the substrate binding sites contain also negatively charged residues that are proposed to be involved in proton transport.
