Paper Citing NAMD - Abstract
Krzysko, K. A.; Kolinski, M.; Filipek, S.
Molecular modelling of the complex of oligomeric rhodopsin and its G protein
JOURNAL OF PHYSICS-CONDENSED MATTER, 19 Art. No. 285204, JUL 18 2007
The TM4 - TM5 model of higher- order structure of rhodopsin ( a structural and functional template for G protein- coupled receptors, GPCRs) in the membrane was used to investigate a complex between oligomeric rhodopsin ( Rh) and its G protein ( transducin, Gt). Comparison with currently available models of oligomeric organization of GPCRs was made, and is discussed with experimental data which revealed a flexible intradimeric Rh interface. We also characterized the membranous anchor domain of Gt in the complex Rh - Gt, which is critically important for the binding of transducin to Rh. ( Some figures in this article are in colour only in the electronic version)
