Structural Biology Software Database
Application Index Record
| Category: Protein Structure Analysis and Verification |
| CONCOORD |
| Last Update: 08-11-2002 |
| Description: CONCOORD is a method to generate protein conformations around a known structure based on distance restrictions. Principal component analyses of Molecular Dynamics (MD) simulations of proteins have indicated that collective degrees of freedom dominate protein conformational fluctuations. These large-scale collective motions have been shown essential to protein function in a number of cases. The notion that internal constraints and other configurational barriers restrict protein dynamics to a limited number of collective degrees of freedom has led to the design of the CONCOORD method to predict these modes without doing explicit, more CPU intensive, MD simulations. |
| Homepage: http://www.mpibpc.gwdg.de/abteilungen/071/bgroot/concoord.html |
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