TCBG Seminar

How the Forces on Proteomes Manifest as Cell Behaviors

Laufer Center for Physical and Quantitative Biology
Stony Brook University
Stony Brook, New York

Monday, November 9, 2020
3:00 pm (CT)
Zoom webinar recording


Cells adapt to their environments.  Adaptive forces in homeostasis or evolution are expressed in terms of growth laws and fitness landscapes.Some aspects of fitness arise from specific actions of individual proteins.  But other aspects arise from more physical, less specific, more universal actions of all proteins in the proteome.  I'll describe modeling of how protein folding, aggregation, diffusion, chaperoning, synthesis and degradation contribute to cellular adaptations.

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