TCB Publications - Abstract

James H. Morrissey, Emad Tajkhorshid, and Chad M. Rienstra. Nanoscale studies of protein-membrane interactions in blood clotting. Journal of Thrombosis and Haemostasis, 9 (Suppl. 1):167-167, 2011. (PMC: PMC3151027)

MORR2011-ET Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these proteinmembrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.

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