TCB Publications - Abstract

Alexander Balaeff, L. Mahadevan, and Klaus Schulten. Elastic rod model of a DNA loop in the lac operon. Physical Review Letters, 83:4900-4903, 1999.

BALA99 We use the theory of elasticity to compute the shape of the DNA loop bridging the gap in the crystal structure of the lac repressor-DNA complex (Lewis et al., 1996). The Kirchhoff system of equations with boundary conditions derived from the crystal structure is solved using a continuation method. This approach can be applied to effectively find coarse-grained conformational minima of DNA loops.

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