Instructor: Emad Tajkhorshid
WF 3:00 - 3:50, Wohlers Hall, room 166
Office hours: Tue 2:00-3:00, Beckman Institute, room 3161
The course will focus on structure-function
relationship of membrane proteins for which three dimensional
structures are known. One of the objectives of the course is to
introduce to students the broad spectrum of information that can be
obtained from structural examination and computer simulation of
membrane proteins. Toward this end, we will first discuss briefly
structure and properties of biological membranes and principles of
membrane-protein interaction. Then, several case studies of membrane
proteins will be presented. For each system, we start with reviewing
the biology and biochemistry of the system, followed by discussion of
the results of simulations, and try to relate them to the function of
the system. A brief methodological discussion will accompany the case
studies, when necessary.
As their term project, students are required to study
a protein of known structure in detail, analyze and understand the
details of the structure carefully, and summarize their findings in a
project paper. Although a membrane protein is preferred for this
purpose, students may choose to work on another protein, if it is
related directly to their research. I would like to encourage students
to also prepare a short presentation (10-15 min) about their system.
Such a presentation is not required, but will positively influence
their final grades.
A database of proteins of known structure along with
their coordinates is maintained by the Protein Data Bank. Lists of membrane
proteins of know structures are compiled by individual research
groups, two of which are mentioned below.
Feel free to contact us if you have questions:
Emad Tajkhorshid: firstname.lastname@example.org ; 244-4361
Markus Dittrich: email@example.com
Please send me your email address, even if you want to only audit
the course without registering. That would enable me to reach you
quickly about last minute changes and announcement, if necessary.