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Introduction
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Aquaporin Tutorial
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Aquaporin Tutorial
Contents
Introduction to Aquaporin Structure
Structure and Function of Aquaporins
Loading other aquaporin structures
Structural Alignment of Aquaporins
Starting Multiple Sequence Alignment
Setting parameters for Multiple Structure Alignments
Aligning the molecules
Comparing Protein Sequence and Structure
Protein Structure
Protein Sequence
Residue Selection
Structure conservation
Sequence conservation
Investigating Structural Alignment
RMSD per Residue
Examining the Aquaporin Tetramer
Loading Tetramer
Examining channel lining and tetrameric contacts
Phylogenetic Tree
Evolutionary Profile of AQPs
Configure BLAST for Multiseq
Load Structures for AQPs in all three domains of life
Load Sequences for AQPs in all three domains of life
Align Sequences Using a Structural Profile
Construct an Evolutionary Profile for AQPs
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