Alchemical transformations and DDG of point mutations

From: Gianluca Interlandi (
Date: Tue Dec 11 2012 - 15:22:37 CST

Dear NAMD list,

I was wondering whether anybody has a reference about how to use free
energy perturbations in order to calculate differences in DeltaG due to
point mutations in globular proteins.



Gianluca Interlandi, PhD
                     +1 (206) 685 4435

Research Scientist at the Department of Bioengineering
at the University of Washington, Seattle WA U.S.A.

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