The web-based collaboratory concept entails a new way of conducting scientific research and implies a new way of interacting with software tools and other researchers ( Star and Ruhleder, 1996 ; Schatz, 1992 ). Unlike traditional research settings, the new problem-solving environment relies on computer-mediated rather than in-person interaction. Design and implementation of BioCoRE depend on a fast and efficient high bandwidth network technology as backbone for distributed web applications. Computational structural biology research involving molecular modeling and simulations, as well as bioinformatics studies will be greatly facilitated by the web-based approach.