From: Alexander Balaeff (abalaeff_at_gmail.com)
Date: Thu May 27 2021 - 13:11:55 CDT
Dear NAMD community:
Black Diamond Therapeutics, a precision oncology medicine company, is
looking for a creative and self-motivated computational chemist with broad
experience to apply her/his expertise and knowledge in the art of
computational chemistry to drug discovery programs. The position is located in
Cambridge, MA, USA. The advertisement is forwarded below. Feel free to
share it with your friends & colleagues, or apply yourself at the link:
As a current employee, I highly recommend this fun and dynamic company as a
great place to work :-)
** Computational Chemist **
Job Locations US-MA-Cambridge
ID 2020-1046 Category Research - Chemistry Type Regular Full-Time
Black Diamond Therapeutics is a precision oncology medicine company
pioneering the discovery and development of small molecule, tumor-agnostic
therapies. Black Diamond targets undrugged mutations in patients with
genetically defined cancers for whom limited treatment options currently
exist. Black Diamond is built upon a deep understanding of cancer genetics,
protein structure and function, and medicinal chemistry. The Companyâ€™s
proprietary technology platform, Mutation-Allostery-Pharmacology, or MAP,
platform, is designed to allow Black Diamond to analyze population-level
genetic sequencing data to identify oncogenic mutations that promote cancer
across tumor types, group these mutations into families and develop a
single small molecule therapy in a tumor-agnostic manner that targets a
specific family of mutations.
The Discovery Team at Black Diamond Therapeutics is looking for a creative
and self-motivated scientist with broad experience to apply her/his
expertise and knowledge in the art of computational chemistry to drug
discovery programs. Reporting to the Director of Computational Chemistry,
and based in our office in Cambridge, USA, the right candidate will support
projects across all stages of discovery from early target selection through
to development candidate nomination. She/he will interact and collaborate
cross-functionally with scientists across the drug discovery organization.
Apply computational techniques to advance projects at all phases of drug
discovery, from target validation and hit generation to lead optimization
and candidate selection
Collaborate with discovery chemists and bioinformaticians to maximize
computational impact on structure-, ligand-, and property-based design of
selective molecules targeting allosteric mutant proteins
Contribute, assist, and advise in the design, evaluation, and
prioritization of new analogues for medicinal chemistry projects.
Build and drive computational strategies to guide the design of small
molecules with improved potency, selectivity, and ADME properties
Develop testable hypotheses and deliver computational tools for predicting
mutant selectivity, ADME, and in vivo pharmacokinetics.
Propose and develop new modeling approaches to enhance existing workflows.
Develop and enhance the cheminformatics and database systems at Black
A Ph.D. in Computational Chemistry or a related discipline
You have spent several years in industry developing and applying modern
computational chemistry and cheminformatics to drug design.
You are an expert in using virtual screening, data mining, machine
learning, pharmacophore development, homology modeling, structure-based and
ligand-based drug design, molecular dynamics.
You are familiar with ORION and software from OpenEye, Python programing,
statistical analysis, and artificial intelligence.
You have a working knowledge of medicinal chemistry and drug discovery
You thrive in a fast-paced, rapidly changing environment.
Excellent written, verbal and presentation skills are required.
Youâ€™re an honest communicator with the ability to present data clearly to
experts and non-experts alike.
You have demonstrated your impact by supporting publications,
presentations, and/or patents.
You have a strategic perspective and demonstrated ability to work in a
rapidly changing, fast-paced environment.
Your interpersonal and communication skills allow you to work effectively
as part of cross functional teams.
You are committed to building and maintaining an energetic, collaborative,
and open culture.
This job operates in a professional office environment. This role routinely
uses standard office equipment.
The physical demands described here are representative of those that must
be met by an employee to successfully perform he essential functions of
While performing the duties of this job, the employee is occasionally
required to stand; walk; sit; used hands to fingers, handle, or feel
objects, tools, or controls; reach with hands and arms; climb be stairs;
talk or hear. The employee must occasionally lift or move office products
and supplies, up to 20 lbs.
Black Diamond Therapeutics is an equal opportunity employer and welcomes
and encourages all applications. Diversity and inclusion are important
core values and will encourage our creativity and growth as a company.
Accommodations are available on request for candidates taking part in all
aspects of the selection process. We thank all applicants for their
interest, however, only those selected will be invited for an interview.
Black Diamond Therapeutics values our relationships with our Recruitment
Partners and will only accept resumes from those partners who have been
contracted by a member of our Human Resources team to collaborate with us.
Black Diamond is not responsible for any fees related to resumes that are
unsolicited or are received by any employee of Black Diamond who is not a
member of the Human Resources team
Dr. Alexander Balaeff Black Diamond Therapeutics
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