Should the windows for ABF calculations be overlapped or not?

From: DAI, JIAN (
Date: Tue Nov 27 2012 - 08:38:17 CST

Dear all:
In the ABF tutorial, the windows are divided so that they are not overlapped. But in a paper by Wereszczynski and McCammon 2011 PNAS, they divide the 2-D conformation space into dozens of overlapping windows. Does the overlapping windows enhance sampling?

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