Breaking of Disulfide Bonds

From: Kapil jain (
Date: Wed May 30 2012 - 23:09:25 CDT

Hi all,

I am running md simulation on homology model of a membrane protein,
following the membrane protein tutorial. During the minimization and
equilibriation with protein constrained, the disulfide bond breaks. What
can be the possible cause for this or does it happens naturally during the
minimization? Are there any means to preserve disulfide bond?


Kapil Jain

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