Re: Determining Transition State from an Unfolding Simulation

From: Richard Wood (
Date: Thu Sep 27 2007 - 07:24:20 CDT

HI Peter, I think you're talking about the biochemists' definition of a TS. When I think of the term "transition state", I think of the intermediate in the reaction A + B ----> products, where there is a "transition state complex" and an energy barrier of a certain height. You people are obviously talking about something different. I'm thinking about the process folded protein ----> unfolded protein (or vice versa), with their being one transition state. The rest of you aren't, I guess. Richard Richard L. Wood, Ph. D. University of Minnesota Dept. of Medicinal Chemistry, College of Pharmacy 717 Delaware St. SE Minneapolis, MN 55414-2959 ____________________________________________________________________________________ Tonight's top picks. What will you watch tonight? Preview the hottest shows on Yahoo! TV.

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