Structural Biology Software Database
Application Index Record
| Category: Protein Structure Analysis and Verification |
| COMPOSER |
| Last Update: 12-31-2000 |
| Description: COMPOSER module provides the tools needed for knowledge-based homology modeling of protein structures. Based on the program developed by Professor Thomas Blundell and colleagues at Birkbeck College, England, Composer uses both sequence and structural information from known families of proteins to predict the 3D structure of an unknown. It is especially useful for extracting all the structural information resident in the members of a family of homologs, and has been shown to build complete, accurate models for proteins with as low as 30% sequence homology. Composer has been shown to generate more complete, accurate models than many of its competitors. Composer is integrated into the SYBYL Molecular Modeling Environment and requires both SYBYL/Base and Biopolymer modules. Analysis of resulting models is enhanced and simplified by the ProTable module. The new GeneFold module uses Composer to build model proteins based on sequence threading technologies. |
| Homepage: http://www.tripos.com/software/composer.html |
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