Christopher G. Mayne, Ph.D.

Home Department:
Beckman Institute for Advanced Science and Technology
Department of Chemistry

Office Address: 3011 Beckman Institute

Office Phone: (217) 300-6380

Email Address: mayne(at)ks(dot)uiuc(dot)edu


Education

  • Post-Doctoral Research Associate, Tajkhorshid Laboratory, University of Illinois at Urbana-Champaign, 2011-2013
  • Ph.D., Chemistry, University of Illinois at Urbana-Champaign, 2011
  • B.S., Chemistry, University of Tennessee at Knoxville, 2004

Research Interests

  • Forcefield Parameterization ( ffTK )
  • Simulating Protein-Ligand Interactions
  • Selective Estrogen Receptor Modulators (SERMs)
  • Drug Discovery
  • Molecular Visualization as an Interactive Educational Tool

  • Publications

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    Madak-Erdogan, Z.; Kim, S-H.; Gong, P.; Zhao, Y.C.; Zhang, H.; Chambliss, K.L.; Carlson, K.E.; Mayne, C.G.; Shaul, P.H.; Korach, K.S.; Katzenellenbogen, J.A.; Katzenellenbogen, B.S. (2016) Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues. Sci. Signal. 9(429), ra53. (Cover Article, Journal Podcast)

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    Mayne, C.G.; Arcario, M.J.; Mahinthichaichan, P.; Baylong, J.L.; Vermaas, J.V.; Navidpour, L.; Wen, P.-C.; Thangapandian, S.; Tajkhorshid,E. (2016) The Cellular Membrane as a Mediator for Small Molecule Interaction with Membrane Proteins. BBA-Biomembranes In Press.

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    Teo, I.; Mayne, C.G.; Schulten, J; Lelièvre, T. (2016) Adaptive multilevel splitting method for molecular dynamics calculation of benzamidine-trypsin dissociation time. J. Chem. Theory Comput. 12(6), 2983-2989.

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    Perilla, J.R.; Hadden, J.A.; Goh, B.C.; Mayne, C.G.; Schulten, K. (2016) All-Atom Molecular Dynamics of Virus Capsids as Drug Targets. J. Phys. Chem. Lett. 7, 1836-1844. (Cover Article)

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    Vermaas, J.V.; Trebesch, N.; Mayne, C.G.; Thangapandian, S.; Baylon, J.; Jian, T.; Wang, Y.; Muller, M.P.; Shinn, E.; Zhao, Z.; Wen, P.-C.; Tajkhorshid,E. (2016) Microscopic Characterization of Membrane Transporter Function by in silico Modeling and Simulation. Methods Enzymol. In Press.

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    Liu, Y.*; Singharoy, A.*; Mayne, C.G.*; Sengupta, A.; Raghavachari, K.; Schulten, K.; Flood, A.H. (2016) Flexibility Coexists with Shape Persistence in Cyanostar Macrocycles. J. Am. Chem. Soc. 138(14), 4843-4851.

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    Hosseinzadeh, P.; Mirts, E.; Pfister, T.; Gao, Y-G.; Mayne, C.G.; Robinson, H.; Tajkhorshid, E.; and Lu, Y. (2016) Enhancing Mn(II)-binding and manganese peroxidase activity in a designed cytochrome c peroxidase through fine-tuning secondary sphere interactions. Biochem. 55(10), 1494-1502.

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    Speltz, T.E; Fanning, S.W.*; Mayne, C.G.*; Fowler, C.; Tajkhorshid, E.; Greene, G.L.; Moore, T.W. (2016) Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angew. Chem. Int. Ed. 55, 4252. ("Hot Paper", Cover Article).

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    Fanning, S.W.*; Mayne, C.G.*; Dharmarajan, V.*; Carlson, K.E.; Martin, T.A.; Novick, S.J.; Toy, W.; Green, B. Panchamukhi, S.; Katzenellenbogen, B.S.; Tajkhorshid, E.; Griffin, P.R.; Shen, Y.; Chandarlapaty, S.; Katzenellenbogen, J.A.; Greene, G.L. (2016) Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation eLife 5, e12792. (Accompanied by a "Related Insight" Article).

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    Yasui, N.; Mayne, C.G.; Katzenellenbogen, J.A. (2015) Preparation of o-Fluorophenols from Nonaromatic Precursors: Mechanistic Considerations for Adaption to Fluorine-18 Radiolabeling Org. Lett. 17(22), 5540-5543.

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    Durrant, J.D.; Carlson, K.E.; Martin, T.A.; Offutt, T.L.; Mayne, C.G.; Katzenellenbogen, J.A.; Amaro, R.E. (2015) Neural-Network Scoring Functions Identify Structurally Novel Estrogen-Receptor Ligands J. Chem. Inf. Model., 55(9), 1953-1961.

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    Kim, S-H.; Madak-Erdogan, Z.; Bae, S-C.; Carlson, K.E.; Mayne, C.G.; Granick, S.; Katzenellenbogen, B.S.; Katzenellenbogen, J.A. (2015) Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate Depend on pH and pH History J. Am. Chem. Soc., 137(32), 10326-10335.

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    Singharoy, A.; Balasubramanian, V.; Liu, Y.; Mayne, C.G.; Lee, S.; Chen, C-H.; Zlotnick, A.; Schulten, K.; Flood, A.H. (2015) Macromolecular Crystallography for Synthetic Abiological Molecules: Combinding xMDFF and PHENIX for Structure Determination of Cyanostar Macrocycles J. Am. Chem. Soc., 137(27), 8810-8818.

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    Aristoff, D.; Lelièvre, T.; Mayne, C.G.; Teo, I. (2015) Adaptive Multilevel Splitting in Molecular Dynamics Simulations ESAIM Proc., 48, 215-225.

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    Arcario, M.J.; Mayne, C.G.; Tajkhorshid, E. (2014) Atomistic models of general anesthetics for use in in silico biological studies J. Phys. Chem. B., 118, 12075-12086.

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    Mayne, C.G.; Saam, J.; Schulten, K.; Tajkhorshid, E.; Gumbart, J.C. (2013) Rapid parameterization of small molecules using the Force Field Toolkit J. Comput. Chem., 34, 2757-2770. (Cover Article, Top-Ten Most-Accessed Article 2014)

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    Moore, T.W.; Mayne, C.G.; Katzenellenbogen, J.A. (2010) Not Picking Pockets: Nuclear Receptor Alternate-Site Modulators (NRASMs) Mol. Endo., 24(4), 683-695. (Cover Article)

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    Zhou, H; Lee, J.H.; Mayne, C.G.; Carlson, K.E.; Katzenellenbogen, J.A. (2010) Imagine progesterone receptor in breast tumors: Synthesis and receptor binding affinity of fluoroalkyl-substituted analogs of Tanaproget J. Med. Chem., 53(8), 3349-3360.

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    Walker, J.V.; Nitiss, K.C.; Jensen, L.H.; Mayne, C.G.; Hu, T.; Jensen, P.B.; Sehested, M.; Hsieh, T.; Nitiss, J.L. (2004) A Mutation in Human Topoisomerase II α Whose Expression Is Lethal in DNA Repair-deficient Yeast Cells. J. Biol. Chem., 275, 25947-25954.


    Materials for Download

    Perform educational simulations of small molecules using NAMD and VMD. Download our collection of molecules: Molecule Set 1.
    Funded by a grant from
    the National Institute of
    General Medical Sciences
    of the National Institutes
    of Health